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What Causes Depression?

Mar 24, 2022

While depression is very common—one out of every ten people suffers from it at some point during the year—it is still a mystery. Almost any negative experience or setback can set off a depressive episode.

External triggers, such as losing a parent (especially while young), losing a career, or having a severe sickness, or internal and invisible triggers, such as obsessing over the most common of experiences, a failed relationship, are examples of external triggers. People's vulnerability varies depending on their biological inheritance, parental heritage, thinking styles, coping skills acquired or intentionally developed, and the degree to which events allow them to affect their fate.



What are the common causes of depression?


The quantity of stressors encountered in life is consistently linked to depression, and the effect is cumulative—the more stressors accumulated over time, the higher the risk of becoming depressed. Most people regard the death or dissolution of a meaningful relationship as a substantial source of stress that necessitates significant adjustment.

Loneliness is a physical and mental stressor, and while it is well-known that loneliness is prevalent among the elderly, it is also on the rise among the young, who increasingly report having few close friends. Job loss or the fear of job loss is a cause of ongoing anxiety for practically everyone. Even tiny bumps on life's road might become huge stressors if you don't have a wide range of coping abilities.



Does depression have a hidden trigger?


Depression can appear out of nowhere for no apparent reason, even though it usually occurs in response to some form of setback. It might even happen when everything seems to be going swimmingly in your life. Basic views about life, love, and labour and ways of interpreting life's twists and turns are frequently hidden from conscious awareness, and many of these beliefs are learned at home during childhood.

Furthermore, people may achieve long-awaited goals only to discover that they do not provide the emotional pleasures they secretly or openly anticipated. People may believe they don't have the right to be depressed in such circumstances, even feeling ashamed of it. Cognitive-behavioural therapy is quite good at uncovering and addressing these kinds of issues.



Can stress bring on depression?


The frequency and severity of main pressures experienced throughout life have been consistently linked to depression in studies. Poverty, for example, is a major, long-term stressor that is difficult to change and is strongly linked to the risk of developing depression. However, attitude significantly affects how people perceive stress to the degree that it is still being researched.

To keep people aware, some stress is required. It's not simply that different conditions stress human systems to various degrees; it's also how people perceive certain situations, such as taking final examinations. People who view stress as a challenge rather than a problem are more likely to summon good emotions rather than negative ones. Additionally, they are immune to the harmful effects of stress hormones on the body and mind.



How do thinking styles influence depression?


These thinking errors, or cognitive distortions, are highly associated with depression. They include obsessing over mistakes or unpleasant experiences, rushing to catastrophic conclusions from one or two setbacks, and overgeneralizing based on insufficient information.

Such thinking suffocates the brain with negativity, breeding self-doubt and misery if left unchecked. Furthermore, research has shown that negative thinking styles like catastrophizing alter physiology. Researchers discovered that they increase levels of the stress hormone cortisol and pro-inflammatory chemicals in the blood and increase response to painful stimulation. Fatigue, delayed reaction time, cognitive sluggishness, and loss of appetite are symptoms of the inflammatory response, which are typically connected with both disease and depression.



Do adverse experiences always result in depression?


According to research, there is a clear link between negative childhood experiences, such as verbal or physical abuse or family disruption caused by a mentally ill parent, and the lifetime risk of depression. Studies have shown verbal abuse to more than double the likelihood of depression throughout one's lifetime. A key source of stress is negative events.

Whether they mobilize resources for effective coping or deplete them relies partly on the situation and the individual. A youngster who is subjected to verbal or physical abuse at home or at school and has no way of escaping the abuse is more likely to become depressed. Situations may be unchangeable, but attitudes, interpretations, and meanings of experiences are always in the hands of the individual and can impart resistance to depression and other diseases.



How does perfectionism lead to depression?


Perfectionism is a never-ending bad grade. Those who are enslaved by it not only have high expectations of themselves, but they are also constant self-critics who constantly pass harsh judgment on themselves. They concentrate on the precise thing they are trying to avoid: failure and bad feedback. Perfectionism keeps people entirely focused on themselves, always finding fault with themselves, preventing them from taking on potentially rewarding challenges.

When perfectionists complete a task, they cannot feel satisfied because their constant worry about making mistakes causes them to be paralyzed by doubts about their abilities—constantly focusing on the negative results in a distorted perspective of themselves, self-doubt, and feelings of worthlessness. Perfectionists are prone to sadness since their self-worth is based on attaining all of their objectives—a condition that they will never achieve by definition.



How does learned helplessness contribute to depression?


Learned helplessness is a mental state in which people believe they have no way of getting out of unpleasant or painful situations, frequently due to childhood abuse or neglect, and hence make no effort to change them, even when it is possible. Passivity as a result of this might prevent people from taking any steps to avoid a problem, aid themselves when one occurs, or seek help from others, compounding their own suffering and precipitating feelings like hopelessness, which are hallmarks of depression. Because helplessness is acquired, the notion that no action matters can be unlearned; a realistic grasp of what can and cannot be managed in life is also part of the healing.



What is inflammation's function in depression?


There's mounting evidence that depression causes inflammation and that the inflammatory response causes or worsens depression. According to neuroscientists, there is a lot of crosstalk between neuronal circuits and inflammatory pathways in the brain. Negative thoughts can cause emotional distress.

Pain, like all other signals of injury, mobilizes a variety of immune cells to assist in subduing the cause, which results in inflammation. An inflammatory reaction is known to be induced by stress. Many antidepressant drugs fail due to the existence of inflammatory cells in the brain; they do not address inflammation.



How does loneliness lead to depression?


Loneliness has many negative effects on the body and psyche. It causes a significant amount of stress and is associated with the release of stress hormones, which have been shown to impair cognitive functions like learning and memory retrieval. Loneliness also amplifies the perception of all other stressors. It impairs immune system function and is a common cause of inflammation, which is a known cause of sadness.

Loneliness causes us to feel sad, and sorrow depletes our energy and causes all body processes to slow down. Loneliness is thought to be even more harmful to one's health than cigarette smoking because companionship is such a great buffer against any human suffering.



What happens in the brain with depression?


A "chemical imbalance" in the brain, according to many individuals, is the source of depression. Experts say that depression is significantly more complicated than that and that thinking of it as a solely biological brain condition is counterproductive.

Instead, depression might be thought of as a behavioural shut down in response to profoundly unpleasant conditions over which you have little personal control, few tools for dealing with them, and limited social support. Memory problems, sluggish thinking, inability to perceive pleasure, lack of food and sex interest, and heightened pain sensitivity are all symptoms of the response.

Neuroimaging studies have shown that depressed persons have altered brain function, which is often linked to deficiencies in connectivity between brain areas that should operate together. Studies have also shown that these changes can be reversed as depression fades.



Are there risk factors for depression?


While heredity is thought to play a role, no one gene or combination of genes has been identified; instead, it appears that a vast number of genes—possibly adjustable by food or behaviour—each contribute a minimal degree of vulnerability that could lead to depression in stressful situations. People who are predisposed to worry excessively, have low self-esteem, are perfectionists, are sensitive to personal criticism, or are self-critical and pessimistic can also be at risk of depression. The attribute of neuroticism is one of the Big Five personality factors that is reliably linked to depression susceptibility. It indicates how easily the negative affect system is triggered. People with high trait neuroticism are more likely to be distressed by events, worry, and doubt themselves in ways that are out of proportion to their circumstances. Furthermore, studies show that women are at a higher risk of depression after a divorce than males and that men are at a higher risk after financial, occupational, or legal difficulties.



Will I be depressed if my mum or father was?


Depression can be passed down down the generations in several different ways. Parents and children may share a set of genes that make them vulnerable to depression. More subtly, parents might engage in depressive thinking and explanatory patterns, which children inadvertently pick up from the air they breathe at home every day.

When women with young children are depressed, there is a lot of evidence indicating they don't engage with their kids. As a result, babies may be unable to form the deep emotional bonds necessary for them to grow, cope with stress, develop emotional regulation, and become responsive to others. The best method to treat difficulties in children is to treat their depressed mothers.



Is there a link between anxiety and depression?


According to experts, anxiety and depression are two sides of the same coin. Both include ruminating on previous events (in sadness) and future events (in anxiety). Sustained anxiety has also been linked to depression. Persistent anxiety affects more than half of all persons who have severe depression. Difficulty concentrating, insomnia, negative thinking, and loss of appetite are only a few of the symptoms shared by the two illnesses. Anxiety is relieved by many of the same medications used to treat depression.



Why is depression becoming more common?


The prevalence of depression is rising, particularly among the young. While there is a 20% lifetime risk of depression, the highest rates are currently found among young adults from 18 to 29, with the lowest rates among those over 65.

Experts point to several factors that make the young particularly vulnerable. They range from social issues such as a lack of a meaningful job to individual variables such as a lack of coping skills resulting from overprotective parenting. There are also cultural considerations. Children's options for free play, in which they experience joy, make friends, learn social skills, and learn how to exercise control over their own lives, have been reduced due to rising safety concerns and a decreased tolerance for risk.



Are women more at risk of depression than men?


Women are 1.7 times more likely than males to experience depression worldwide, and this disparity begins in adolescence. Although boys and females have equal rates of depression before puberty, the gender disparity in depression is significantly more significant in younger women. Social, cultural, and biological factors have all been identified in studies.

Internalizing symptoms, such as physical pain and other somatic problems, social withdrawal, and self-blame, are more common in women, whereas externalizing symptoms, such as irritability, hostility, aggression, and drug abuse, are more common in men. Furthermore, childbirth is linked to a specific type of depression, which is thought to be connected in part to the rapid hormonal changes that occur postpartum and the significantly increased demands of new motherhood.


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